GMC Sierra 1500 Key Replacement Guide

Last updated: August 2026 · Verified OEM part numbers

Quick answer: The GMC Sierra 1500 (2021-2022) uses the YG0G21TB2 433MHz 49 Chip 4+Panic Button (Pickup) Smart Key for GMC Sierra 1500 (SKU PCK-GC-2006-O) — verified against OEM part numbers. See the full compatibility table below.

Compatible keys for GMC Sierra 1500

Before you order

• Match the year range — GMC changed key systems across model years. Check your registration year.
• Check your current key — the OEM number printed on your key matches the table above.
• Programming — smart keys need a compatible programmer (Xhorse, VVDI, Autel). We can advise which one works for each key.

Frequently asked questions

Which key fits my GMC Sierra 1500?

The GMC Sierra 1500 (2021-2022) uses the YG0G21TB2 433MHz 49 Chip 4+Panic Button (Pickup) Smart Key for GMC Sierra 1500 (SKU PCK-GC-2006-O). Check the table above for all compatible options, verified against OEM part numbers.

Do you supply GMC Sierra 1500 keys wholesale?

Yes. We supply locksmiths and key distributors at wholesale prices with MOQ from 5 units. Message us on WhatsApp for today's price list.

Can a GMC Sierra 1500 key be programmed without the dealer?

In most cases yes, using tools like Xhorse, VVDI or Autel. We can advise the right programmer for each key SKU.

Related: All GMC keys · All guides · Key Finder

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